
H 89 2HCl
CAS No. 130964-39-5
H 89 2HCl( 5-Isoquinolinesulfonamide | Protein Kinase Inhibitor H-89 )
Catalog No. M11238 CAS No. 130964-39-5
H 89 2HCl is a potent PKA inhibitor with Ki of 48 nM, 10-fold selective for PKA than PKG.
Purity : >98% (HPLC)






Size | Price / USD | Stock | Quantity |
5MG | 30 | In Stock |
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10MG | 48 | In Stock |
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25MG | 97 | In Stock |
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50MG | 192 | In Stock |
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100MG | 327 | In Stock |
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200MG | 484 | In Stock |
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500MG | 771 | In Stock |
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1G | Get Quote | In Stock |
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Biological Information
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Product NameH 89 2HCl
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NoteResearch use only, not for human use.
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Brief DescriptionH 89 2HCl is a potent PKA inhibitor with Ki of 48 nM, 10-fold selective for PKA than PKG.
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DescriptionH 89 2HCl is a potent PKA inhibitor with Ki of 48 nM, 10-fold selective for PKA than PKG, greater than 500-fold selectivity than PKC, MLCK, calmodulin kinase II and casein kinase I/II.(In Vitro):H-89 inhibits protein kinase A, in competitive fashion against ATP. H-89 causes a dose-dependent inhibition of the forskolin-induced protein phosphorylation, with no decrease in intracellular cyclic AMP levels in PC12D cells. H-89 significantly inhibits the forskolin-induced neurite outgrowth from PC12D cells. H-89 (30 μM) inhibits significantly cAMP-dependent histone IIb phosphorylation activity in PC12D cell lysates. H-89 (1-2 μM) significantly slows the repriming rate in rat skinned fibres, most likely due to it deleteriously affecting the T-system potential. H-89 (10-100 μM) inhibits net Ca2+ uptake by the SR and affectes the Ca2+-sensitivity of the contractile apparatus in rat skinned fibres.(In Vivo):H-89 (0.2 mg/100g, i.p.) significantly increases seizure latency and threshold in PTZ-treated animals. H-89 (0.05, 0.2 mg/100 g, i.p.) prevents the epileptogenic activity of bucladesine (300 nM) with significant increase of seizure latency and seizure threshold.
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In VitroH-89 inhibits protein kinase A, in competitive fashion against ATP. H-89 causes a dose-dependent inhibition of the forskolin-induced protein phosphorylation, with no decrease in intracellular cyclic AMP levels in PC12D cells. H-89 significantly inhibits the forskolin-induced neurite outgrowth from PC12D cells. H-89 (30 μM) inhibits significantly cAMP-dependent histone IIb phosphorylation activity in PC12D cell lysates. H-89 (1-2 μM) significantly slows the repriming rate in rat skinned fibres, most likely due to it deleteriously affecting the T-system potential. H-89 (10-100 μM) inhibits net Ca2+ uptake by the SR and affectes the Ca2+-sensitivity of the contractile apparatus in rat skinned fibres.
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In VivoH-89 (0.2 mg/100g, i.p.) significantly increases seizure latency and threshold in PTZ-treated animals. H-89 (0.05, 0.2 mg/100 g, i.p.) prevents the epileptogenic activity of bucladesine (300 nM) with significant increase of seizure latency and seizure threshold.
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Synonyms5-Isoquinolinesulfonamide | Protein Kinase Inhibitor H-89
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PathwayApoptosis
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TargetPKA
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RecptorPKA| S6K1
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Research AreaOther Indications
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Indication——
Chemical Information
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CAS Number130964-39-5
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Formula Weight519.28
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Molecular FormulaC20H20BrN3O2S.2HCl
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Purity>98% (HPLC)
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SolubilityDMSO:104 mg/mL (200.27 mM); Ethanol:<1 mg/mL (<1 mM); Water:6 mg/mL (11.55 mM)
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SMILESC1=CC2=C(C=CN=C2)C(=C1)S(=O)(=O)NCCNC/C=C/C3=CC=C(C=C3)Br.Cl.Cl
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Chemical Name——
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1.Chijiwa T, et al. J Biol Chem., 1990, 265(9), 5267-5272.
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